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This comprehensive book introduces the revolutionary impact of DNA microarray technology in the field of cancer research, focusing on its utilization for gene expression profiling. Authored by leading experts within their respective disciplines, this volume presents an insightful exploration of related to DNA array manufacturing as well as its practical applications in oncology.
The text delves into several key areas:
Manufacturing and : It starts with a detled explanation on the fabrication processes of microarrays. This foundational knowledge enables researchers to understand how these technologies are designed, optimized, and utilized effectively for various scientific inquiries.
Technological Platforms: A review of platforms suitable for gene expression profiling is provided alongside discussions on the importance of choosing the right technology based on specific research objectives.
Data Analysis: The authors expln methodologies for analyzing microarray data. They emphasize techniques that help extract meaningful insights from large datasets, essential skills needed to interpret biological phenomena accurately.
Integration with Clinical Data: Insights into how DNA microarrays can be integrated with clinical and genomic information to improve patient diagnostics and treatment decisions are shared.
Chapters cover advanced topics such as the use of complementary technologies like PCR, SNP analysis, and methods for identifying molecular determinants affecting tumor sensitivity or resistance to anticancer drugs. The book also addresses challenges in using this technology effectively.
Throughout the book, there is a strong focus on how DNA microarray technology can help advance our understanding of cancer development, progression, and diagnosis, offering researchers new hypotheses that may ultimately influence clinical management strategies for patients with various types of cancers, including lymphomas.
This book serves as a crucial resource for scientists involved in molecular biology, bioinformatics, medical research, and healthcare professionals ming to harness the power of microarray technology for their work. It provides both foundational knowledge and advanced insights necessary for those working towards advancing cancer diagnosis and treatment strategies through gene expression profiling studies.
The information provided assumes familiarity with scientific terminology related to microarrays, genetics, and bioinformatics. To fully benefit from this material, readers should have a background in molecular biology or equivalent knowledge.
This article is reproduced from: https://link.springer.com/content/pdf/10.1007/978-0-387-39978-2.pdf
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Microarray Technology Cancer Research Impact Gene Profiling in Oncology Field Manufacturing Processes for DNA Arrays Advanced Data Analysis Techniques Used Clinical Integration of Array Data Identifying Molecular Determinants for Drug Sensitivity