Exploring Cancer Pathology: Decoding the Role of Epigenetics in Therapeutic Targets Identification

Title: Decoding the Epigenetic Landscape: Elucidating Cancer Pathology and Identifying Novel Therapeutic Targets

Overview:

Epigenetic modifications encompass a spectrum of mechanisms that influence gene expression without altering DNA sequences. These include, but are not limited to, DNA methylation, histone modifications, variations in DNA replication timing, nucleosome positioning, changes in heterochromatin states, and the modulation of chromatin structure. Such epigenetic alterations play pivotal roles in cancer development by affecting cellular processes such as cell cycle regulation, apoptosis, and genomic stability.

Manuscript Submission Deadline: December 9th, 2024

Topic Editors:

Yichao Hou - Shangh Ninth People’s Hospital, Shangh Jiaotong University School of Medicine

Shangh, China

Han Yao - Shangh Ninth People’s Hospital, School of Medicine, Shangh Jiao Tong University

Shangh, China

Dawei Chen - Institute of Clinical Molecular Biology, Faculty of Medicine, University of Kiel

Kiel, Germany

Call for Manuscripts:

We are inviting submissions to a Research Topic focusing on the exploration and understanding of cancer pathology through the lens of epigenetics. The objective is to identify novel therapeutic targets by delving into how epigenetic modifications contribute to various stages of tumor development.

ms and Scope:

1. Mechanisms of Epigenetic Regulation in Cancer: Investigate the biological mechanisms underlying how specific epigenetic alterations e.g., DNA methylation, histone modifications drive cancer progression.

2. Novel Therapeutic Targets Identification: Explore potential new targets for cancer therapy by leveraging insights into altered epigenetic landscapes found in cancer cells compared to normal tissue counterparts.

3. Innovative Treatment Approaches Based on Epigenetics: Discuss the development of innovative therapeutics that specifically target epigenetic mechanisms or pathways as a means of treating cancer.

4. Case Studies and Clinical Applications: Provide real-world examples where targeted therapies have been successful in clinical settings based on understanding of the epigenetic landscape.

5. Future Directions in Epigenetic Cancer Research: Outline future research directions, including technological advancements that could d in better identifying and targeting specific epigenetic modifications for cancer treatment.

Instructions for Authors:

Submissions should be prepared according to our journal's guidelines, which are avlable on the Frontiers website. Manuscripts can be submitted via any of our participating journals listed below.

• Frontiers in Pharmacology: Focuses on all aspects of pharmacology including drug discovery, pharmacokinetics, and clinical pharmacology.

• Frontiers in Oncology: Concentrates on cancer research encompassing molecular biology, genetics, diagnosis, treatment strategies, patient care, and more.

Citation Examples:

Example:

Huo, M., Zhang, M., Zhang, J., Wang, Y., Hu, T., Ma, T., Wang, Y., Yuan, B., Qin, H., Teng, X., Yu, H., Huang, W., Wang, Y. 2024. Prognostic analysis of patients with gastric cancer based on N6-methyladenosine modification patterns and tumor microenvironment characterization. Frontiers in Pharmacology, DOIhttps:doi.org10.3389fphar.2024.1445321.

Publishing Fees:

All manuscripts submitted to Frontiers are subject to the application of our open-access publishing fees, which ensure that research is freely accessible worldwide.

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that all submission deadlines, instructions for authors, and links will be accessible upon actual publication of this call in the Frontiers platform. This notice serves as a preliminary guide only and may be updated with more comprehensive information closer to the date of publication.

notes:

This Research Topic compile cutting-edge research from diverse disciplines, fostering interdisciplinary collaboration that can accelerate advancements in epigenetic cancer therapy. Whether you're a researcher looking to contribute original data or insights into the field, or interested in exploring how existing knowledge could be translated into innovative therapies, this call is designed to accommodate your contributions.

of Call for Manuscripts
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